The local industry is represented by ten companies. The two major enterprises, Skidel Sugary and Skidelsky agricultural company, produce 80% of the industrial output in the district. Grodno District is the main sugar producer in the region. Food industry dominates in the region, it accounts for more than 85% of the regional production volume.
Diversified foreign trade is supported by strong trade and economic cooperation with the regions of the non-CIS and CIS states, first of all, the Russian Federation.
The district has 509 private companies, 1142 sole traders, 18 joint and foreign companies with the capital from the USA, England, Ireland, Poland, Lithuania, Cyprus, Russia.